Process for the enzymatic synthesis of alkyl esters of peptides and peptides, and microparticles therefrom
US5554508A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 31, 1994 |
| Grant date | Sep 10, 1996 |
| Priority date | — |
| Expiry date | Oct 31, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/22002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for the simultaneous enzymatic synthesis of a mixture of alkyl esters of peptides and peptides is presented. In the process, a protein substrate and at least one aliphatic alkanol having from 1 to 5 carbon atoms at a concentration of more than about 30% V/V, preferably 70% V/V to 90% V/V, are treated with a serine protease. A mixture of alkyl esters of peptides and peptides having an esterification value of at least 25% and an average molecular mass of about 3,000 to about 10,000 daltons is recovered. In a further step, the mixture of alkyl esters of peptides and peptides may be precipitated from an alcoholic medium, in an aqueous phase to prepare microparticles. The mixture of alkyl esters of peptides and peptides, or the microparticles may be used in cosmetic, food, pharmaceutical, wetting agent, film-agent, or emollient compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.