N-(hydroxyethyl)butanediamide derivatives
US5554634A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 1, 1995 |
| Grant date | Sep 10, 1996 |
| Priority date | — |
| Expiry date | May 1, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein are compounds of the formula: EQU A'--N(R.sup.1')c(O)CH.sub.2 CHR.sup.2 C(O)--B wherein A' is HO--CR.sup.5 (R.sup.6)CH.sub.2 wherein R.sup.5 and R.sup.6 together with the carbon atom to which they are attached form a 1,1-(lower cycloalkanediyl); R.sup.1' is R.sup.7 R.sup.8 NC(O)CH.sub.2 wherein R.sup.7 hydrogen or lower alkyl and R.sup.8 is lower alkyl; R.sup.2 is, for example, 4-thiazolylmethyl or (2-amino-4-thiazolyl)methyl; and B is a renin substrate transition state mimic, for example, [1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]amino. The compounds inhibit renin activity and are indicated for the treatment of hypertension and congestive heart failure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.