Process for the stereoselective synthesis of 3-substituted 2-thiomethylpropionic acids

US5554788A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Holla · Kelkheim, DE
• Bernhard Kammermeier · Frankfurt, DE
• Gerhard Beck · Frankfurt am Main, DE

Key dates

• Filing date: May 15, 1995
• Grant date: Sep 10, 1996
• Expiry date: May 15, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D263/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Process for the stereoselective synthesis of 3-substituted 2-thiomethylpropionic acids Compounds of the formula I ##STR1## in which R.sup.1 and R.sup.2 are as defined can be prepared stereoselectively by reaction of acrylic acid or derivatives thereof or propionic acid or derivatives thereof with a chiral auxiliary, reaction with a mercaptan, stereoselective alkylation and subsequent hydrolysis and oxidation.