YIGSR peptide radiopharmaceutical applications

US5556609A · kind A · utility

Assignee

• Rhomed Incorporated · US

Inventor

• Paul O. Zamora · Gaithersburg, US

Key dates

• Filing date: Dec 30, 1992
• Grant date: Sep 17, 1996
• Expiry date: Dec 30, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

RACT, J. Nucl. Med., vol. 34, No. 5, (1993), Abstract No. 1133. Zamora, P. O, et al., "Biological distribution of .sup.99m Tc-labeled YIGSR and IKVAV laminin peptides in rodents: .sup.99m Tc-IKVAV peptide localize to the lung", Biochemica et Biophysica Acta, vol. 1182, No. 2 (1993), pp. 197-204. Sandrock, B., "Kinetics of I. V. Injected 1-131-Labeled Laminin-C.sub.1 -Fragmen in Normal and Tumor-Bearing Nude Mice," Proceedingsof the AACR,vol. 30, Abstract No. 390 (1989). Liotta, Lance A., et al., "Laminin Receptors on Human Breast Carcinoma: Role in Invasion of the Extracellular Matrix", Understanding Breast Cancer: Clinical and Laboratory Concepts, Rich, N, et al (ed.), pp. 87-97 (1983). Zamora, P. O., et al., "A Second Tc-99m Binding Site in IgG Is Related To Distadine Groups," J. Nucl. Med., vol. 33, No. 5 (1992), Abstract No. 86. Swanson, D., et al "Laminin Peptide Fragments for Malignant Tumor Detection", Proc. of 40th Ann. Meet., Journal of Nuclear Medicine, vol. 34, No. 5, p. 231P (May 1993). Fischman, Alan J., et al., "A Ticket to Ride: Peptide Radiopharmaceuticals," J. Nucl. Med., vol. 34, No. 12, pp. 2253-2263 (Dec. 1993). LREP FR2 Peacock; Deborah A. FR2 Hegge; David P.