Antibody-drug conjugates
US5556623A · kind A · utility
24Cited by
6References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 30, 1993 |
| Grant date | Sep 17, 1996 |
| Priority date | — |
| Expiry date | Mar 30, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6889
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Immunoconjugates of antibodies or antigen-recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of .beta.-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an ester or amide group and the drug is attached through the linker's 2-position methylene group. Intermediates, compositions and methods of use also are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.