Methods of enhancing wound healing and tissue repair
US5556645A · kind A · utility
Inventors
Key dates
| Filing date | Apr 26, 1995 |
| Grant date | Sep 17, 1996 |
| Priority date | — |
| Expiry date | Apr 26, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L26/0004
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Skin, connective and support tissue repair is enhanced and augmented by administering pharmaceutically acceptable gallium-containing compounds in amounts sufficient to provide therapeutic levels of elemental gallium. Gallium-containing compounds mimic the effects of endogenous growth factors to induce cells within these tissues to produce new matrix by increasing the formation of critical structural matrix proteins responsible for skin, support and connective tissue repair, maintenance and augmentation. Gallium-containing compounds are suitable for a variety of applications in wound healing, including dermatologic and cosmetic skin repair, bone fracture repair and successful bonding of implanted tissue grafts and connective and support tissue prostheses. The unique ability of the gallium-containing compounds to increase new matrix component formation and favorably alter the proliferation of specific cell types needed for tissue repair is separate and distinct from gallium's inhibitory activity on matrix-resorbing cells such as bone-resorbing osteoclasts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.