Surface-bound, unimolecular, double-stranded DNA
US5556752A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 24, 1994 |
| Grant date | Sep 17, 1996 |
| Priority date | — |
| Expiry date | Oct 24, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/551
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific interactions between the double-stranded oligonucleotides, and peptides, proteins, drugs and RNA. In a related aspect, the present invention provides libraries of conformationally restricted probes on a solid support. The probes are restricted in their movement and flexibility using double-stranded oligonucleotides as scaffolding. The probes are also useful in various screening procedures associated with drug discovery and diagnosis. The present invention further provides methods for the preparation and screening of the above libraries.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.