DNA encoding human .alpha..sub.1 adrenegric receptors and uses thereof

US5556753A · kind A · utility

Assignee

• Synaptic Pharmaceutical Corporation · US

Inventors

• Jonathan Bard · New York, US
• Carlos Forray · Paramus, US
• Richard L. Weinshank · Teaneck, US

Key dates

• Filing date: Nov 4, 1994
• Grant date: Sep 17, 1996
• Expiry date: Nov 4, 2014

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides an isolated nucleic acid molecule encoding a human .alpha..sub.1a adrenergic receptor, an isolated nucleic acid molecule encoding a human .alpha..sub.1b adrenergic receptor and an isolated nucleic acid molecule encoding a human .alpha..sub.1c adrenergic receptor, an isolated protein which is a human .alpha..sub.1a adrenergic receptor, an isolated protein which is .alpha..sub.1b adrenergic receptor and a isolated protein which is a human .alpha..sub.1c adrenergic receptor, vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1a adrenergic receptor, vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1b adrenergic receptor, and vectors comprising an isolated nucleic acid molecule encoding a human .alpha..sub.1c adrenergic receptor, mammalian cells comprising such vectors, antibodies directed to the human .alpha..sub.1a adrenergic receptor, antibodies directed to the human .alpha..sub.1b adrenergic receptor, and antibodies directed to the human .alpha..sub.1c adrenergic receptor, nucleic acid probes useful for detecting nucleic acid encoding a human .alpha..sub.1a adrenergic receptor, nucleic acid probe…