Inhibiting the development of tolerance to and/or dependence on an addictive substance
US5556838A · kind A · utility
221Cited by
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2Claims
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Assignee
Inventors
Key dates
| Filing date | May 19, 1994 |
| Grant date | Sep 17, 1996 |
| Priority date | — |
| Expiry date | May 19, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e.g., a ganglioside such as GM.sub.1 or GT.sub.1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.