Patent · US Expired

2',5'-phosphorothioate oligoadenylates as anitiviral agents

US5556840A · kind A · utility

4Cited by

8References

12Claims

0Family size

Assignee

Temple University-Of The Commonwealth System of Higher Education · US

Inventors

Robert J. Suhadolnik · Roslyn, US
Wolfgang Pfleiderer · Konstanz, DE

Key dates

Filing date	Dec 2, 1994
Grant date	Sep 17, 1996
Priority date	—
Expiry date	Dec 2, 2014

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P31/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Optically active compounds of the formula ##STR1## wherein n is 1 or 2 and m is 0, 1, 2 or 3 have antiviral activity. Compounds of the formula wherein at least one of the internecleotide phosphorothioate linkages is of the Sp configuration possess increased antiviral activity and/or metabolic stability.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.