Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors
US5556847A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 27, 1994 |
| Grant date | Sep 17, 1996 |
| Priority date | — |
| Expiry date | Oct 27, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/57
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention discloses a method for treating a patient for an illness selected from the group consisting of amnesia, head injuries, Alzheimer's disease, epileptic dementia, presenile dementia, post traumatic dementia, senile dementia, vascular dementia and post stroke dementia or individuals otherwise seeking memory enhancement. The method comprises providing a compound of formula (1) ##STR1## wherein (a) R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of hydrogen and a lower alkyl group of 1 to 6 carbon atoms and (b) the ring system ABCD is asteroid nucleus selected from the group consisting of estrone, dehydroepiandrosterone, estradiol, estradiolester, pregnenolone, substituted estrone, substituted dehydroepiandrosterone, substituted estradiol, substituted estradiolesters and substituted pregnenolone. The invention also discloses the enhancement of memory by the steroid sulfatase inhibitors of the invention acting synergistically with the naturally occurring neurosteroids dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate (PS).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.