Glycopeptide derivatives, a process for their preparation and pharmaceutical agents containing these compounds

US5556941A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Cenek Kolar · Marburg, DE
• Werner Stuber · Lahntal, DE

Key dates

• Filing date: Aug 16, 1994
• Grant date: Sep 17, 1996
• Expiry date: Aug 16, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Glycopeptide derivatives, a process for their preparation and pharmaceutical agents containing these compounds N-Glycopeptide derivatives of the formula I ##STR1## where aromatic is an unsubstituted or substituted benzene residue, naphthalene residue, chroman residue, chromene residue or coumarone residue, PA1 a is 0 to 5, b is 0 to 4, c is 0 or 1, d is 1 or 2 PA1 R.sup.1 is (C.sub.1 -C.sub.3)-alkyl, PA1 R.sup.2 is (C.sub.1 -C.sub.3)-alkyl or (C.sub.1 -C.sub.3)-alkyloxy, PA1 R.sup.3 is H, OH, (C.sub.1 -C.sub.3)-alkyloxy, NH.sub.2, NH-(C.sub.1 -C.sub.6)-alkanoyl, NH-benzoyl, NH--SO.sub.3 H or NH-acyl radical of a natural N-acetylated amino acid, PA1 R.sup.4 is H, OH, or (C.sub.1 -C.sub.3)-alkyloxy, PA1 R.sup.5 is H, OH, (C.sub.1 -C.sub.3)-alkyloxy, fluorine, chlorine or bromine, PA1 R.sup.6 is H, CH.sub.3, CH.sub.2 OH, CH.sub.2 O--(C.sub.1 -C.sub.6), CH.sub.2 NHCOCH.sub.3 or CH.sub.2 NH--SO.sub.3 H, PA1 R.sup.5 and R.sup.6 are together O--CH.sub.2 --O--CH.sub.2, --O--CH(CH.sub.3)--O--CH.sub.2 or O--C(CH.sub.3).sub.2 --O--CH.sub.2, PA1 R.sup.7 is hydroxy-(C.sub.2 -C.sub.4)-alkyl or (C.sub.2 -C.sub.4)-alkyloxy-(C.sub.2 -C.sub.4)-alkyl, PA1 R.sup.8 is H or (C.sub.1 -C.sub.6)-alkyl or P…