Methods and compositions relating to the androgen receptor gene and uses thereof
US5556956A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 4, 1993 |
| Grant date | Sep 17, 1996 |
| Priority date | — |
| Expiry date | Nov 4, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3515
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are methods and compositions, including antisense and antigene constructs and pharmaceutical formulations thereof, for use in regulating androgen receptor gene expression. The promoter activity of the androgen receptor gene is herein shown to include a critical upstream acting domain with a unique sequence, the unique nucleic acid sequence corresponding to positions 1697 and 2084, particularly between positions 1697 and 1717, as defined in SEQ ID NO:1. The AR gene promoter sequence, herein characterized as having a a particular nucleotide sequence defined between nucleotides 1697 and 2084 of SEQ ID NO:1, is characterized as important in the regulation of androgen receptor gene expression. Oligonucleotides and triple helix forming oligonucleotides (TFO) that bind to this region and that have nucleic acid sequences corresponding particularly to the region between positions 1697 and 2084 of the androgen receptor gene promoter region provide specific and potent inhibition of AR promoter region function in cellulo. Rat and human nuclear proteins, more specifically described as novel trans-activating proteins that specifically bind to this region of the androgen receptor gene, …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.