Compounds for the photodecontamination of pathogens in blood

US5556993A · kind A · utility

Assignee

• The Steritech Group, Inc. · US

Inventors

• Susan Wollowitz · Walnut Creek, US
• Stephen T. Isaacs · Orinda, US
• Henry Rapoport · Berkeley, US
• Hans Peter Spielmann · Lexington, US
• Aileen Nerio · Fremont, US

Key dates

• Filing date: Jun 5, 1995
• Grant date: Sep 17, 1996
• Expiry date: Jun 5, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2/0011
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Psoralen compounds are synthesized which have substitutions on the 4,4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in safer, more efficient, and reliable inactivation of pathogens in blood products. The invention contemplates inactivation methods using the new psoralens which do not compromise the function of blood products for transfusion.