Microbial reduction of benzazepines and benzothiazepine derivatives
US5559017A · kind A · utility
2Cited by
8References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 19, 1990 |
| Grant date | Sep 24, 1996 |
| Priority date | — |
| Expiry date | Nov 19, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/911
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
. A novel process comprises reducing a benzazepine or benzothiazepine at the 3-position in d-cis configuration by treatment with reductase-supplying microorganisms or enzymes derived therefrom. The process can be catalyzed in a single stage by growing microbial cultures or in a two-stage fermentation/transformation by resting cell-suspensions. The enzymes derived from the microorganisms can be used in free state or immobilized form. The microorganisms and enzymes catalyzes the specific reduction with 90 to 99% conversion efficiency to 99% or greater optical purity of the desired enantiomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.