Delayed treatment method of reducing ischemia-related neuronal damage
US5559095A · kind A · utility
24Cited by
1References
5Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 12, 1991 |
| Grant date | Sep 24, 1996 |
| Priority date | — |
| Expiry date | Nov 12, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method and compositions for reducing neuronal damage related to an ischemic condition in a mammalian subject are described. The method includes administration of a voltage-gated calcium channel-blocking compound to the subject, 4-24 hours after the onset of the ischemic condition. Such a calcium channel blocking compound is effective to block norepinephrine release in mammalian CNS neuronal cells and is characterized by specific, high affinity binding to omega-conotoxin MVIIA binding sites. Also disclosed are novel peptide structures useful in the treatment method of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.