Cephalosporin derivatives

US5559108A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Choung U. Kim · Redwood City, US
• Muzammil M. Mansuri · Lexington, US
• Peter F. Misco · Syracuse, US
• John A. Wichtowski · Saint Albans, US
• Joanne J. Bronson · Madison, US
• Stanley D'Andrea · Middletown, US
• Thomas W. Hudyma · Durham, US

Key dates

• Filing date: May 22, 1995
• Grant date: Sep 24, 1996
• Expiry date: May 22, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## where Ar is a substituted phenyl or optionally substituted naphthyl or benzthiazolyl group and A is a substituted-pyridinium group are gram-positive antibiotics, especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus.