Resolution of (RS)-ibuprofen by Candida antarctica catalyzed esterification with long chain alcohols while removing water
US5561057A · kind A · utility
5Cited by
2References
6Claims
0Family size
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Inventors
Key dates
| Filing date | Sep 20, 1994 |
| Grant date | Oct 1, 1996 |
| Priority date | — |
| Expiry date | Sep 20, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/005
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention disclosed relates to a process for the enzymatic esterification and transesterification of racemic carboxylic acids and alcohols in which the reaction products predominantly include the ester of the more reactive acid or alcohol enantiomer and the less reactive acid or alcohol enantiomer, wherein the reactions are effected, preferably in a solventless medium, and the by-product water or short-chain alcohol is removed as it is formed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.