4-aryloxy- and 4-arylthiopiperidine derivatives

US5561145A · kind A · utility

Assignee

• MERCK PATENT GESELLSCHAFT MIT BESHRANK TER HAFTUNG · DE

Inventors

• Helmut Prucher · Heppenheim, DE
• Rudolf Gottschlich · Reinheim, DE
• Gerd Bartoszyk · Weiterstadt, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE

Key dates

• Filing date: Jul 21, 1994
• Grant date: Oct 1, 1996
• Expiry date: Jul 21, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel 4-aryloxy- or 4-arylthiopiperidine derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2 are each, independently of one another, phenyl radicals which are unsubstituted or mono or disubstituted by A, OH, OA, aryloxy with 6-10 C atoms, aralkyloxy with 7-11 C atoms, --0--(CH.sub.2).sub.n --0--, Hal, CF.sub.3, NO.sub.2, NH.sub.2, NHA, NA.sub.2, NHAc, NAAc, NHSO.sub.2 A and/or NASO.sub.2 A, PA1 X is O, S, SO or SO.sub.2, PA1 m is 1, 2 or 3, PA1 n is 1 or 2, PA1 A is an alkyl radical with 1-6 C atoms, PA1 Hal is F, Cl, Br or l and PA1 Ac is alkanoyl with 1-8 C atoms, aralkanoyl with 1-10 C atoms or aroyl with 7-11 C atoms, and the physiologically acceptable salts thereof, show an effect influencing the central nervous system, in particular neuroleptic effect, with a negligible cataleptic effect.