Urea/lactate topical compositions for dry skin

US5561166A · kind A · utility

Assignee

• BEIERSDORF AG · DE

Inventors

• Henning Sattler · Hamburg, DE
• Horst Wenck · Norderstedt, DE
• Sven Thormahlen · Greenwich, US
• Karlheinz Schrader · Holzminden, DE

Key dates

• Filing date: Jul 28, 1993
• Grant date: Oct 1, 1996
• Expiry date: Jul 28, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K8/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and compositions for the treatment of dry skin involve the topical application to affected sites of a composition comprising from about 1% to about 12% by weight of urea and from about 1% to about 10% by weight of and alkali or an earth metal salt of lactic acid such as sodium, potassium or calcium lactate or a mixture of these salts in water-in-oil emulsions. In lotion embodiments, the emulsion typically contains from about 1% to about 10% by weight, more narrowly from about 2% to about 5% by weight, lactate and from about 1% to about 10% by weight, more narrowly from about 2% to about 5% by weight, urea. In cream embodiments, the emulsion typically contains from about 1% to about 5% by weight, more narrowly from about 2% to about 4% by weight, lactate, and from about 3% to about 15% by weight, more narrowly from about 5% to about 10% by weight, urea. Application of the compositions of the invention to the skin controls transepidermal water loss and minimizes disturbance of the epidermal barrier layer.