Boronic acid and ester inhibitors of thrombin

US5563127A · kind A · utility

Assignee

• The DuPont Merck Pharmaceutical Company · US

Inventors

• Eugene C. Amparo · West Chester, US
• William Henry Miller · Collegeville, US
• Gregory J. Pacofsky · Raleigh, US
• John Wityak · Carlsbad, US
• Patricia C. Weber · Yardley, US
• John J. V. Duncia · Newark, US
• Joseph B. Santella · Springfield, US

Key dates

• Filing date: Dec 27, 1994
• Grant date: Oct 8, 1996
• Expiry date: Dec 27, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel boronic acid and ester and carboxyl-modified amino acid compounds of the Formula I, which are inhibitors of trypsin-like enzymes, are disclosed : EQU R.sup.1 --Z--CHR.sup.2 --A, where R.sup.1, Z, R.sup.2 and A are defined within.