Heterobiaryl derivatives

US5563268A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Guenter Linz · Mittelbiberach, DE
• Helmut Pieper · Lohr am Main, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Volkhard Austel · Biberach, DE
• Thomas Mueller · Zell am Harmersbach, DE
• Johannes Weisenberger · Biberach, DE
• Elke Seewaldt-Becker · Biberach, DE

Key dates

• Filing date: Jan 19, 1995
• Grant date: Oct 8, 1996
• Expiry date: Jan 19, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/650905
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Heterobiaryl derivatives of the formula EQU R.sub.1 NH--X.sub.1 --X.sub.2 --X.sub.3 --Y.sub.1 --Y.sub.2 --Y.sub.3 --Y.sub.4 --E (I) wherein PA1 R.sub.1, X.sub.1 to X.sub.3 and Y.sub.1 to Y.sub.4 are as defined herein, the tautomers, stereoisomers and mixtures thereof, and the salts, particularly the physiologically acceptable salts, thereof with organic or inorganic acids or bases. The derivatives have valuable pharmacological properties, such as inhibiting cell-cell aggregation and cell-matrix interactions.