Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5565552A · kind A · utility
303Cited by
29References
29Claims
0Family size
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Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Oct 15, 1996 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3511
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to a method of incorporating expanded porphyrins, and particularly of incorporating a sapphyrin or a texaphyrin, before, during, or after chemical synthesis of an oligomer to form an expanded porphyrin-oligonucleotide conjugate, and particularly a sapphyrin- or texaphyrin-oligonucleotide conjugate. This method includes reacting derivatized nucleotides and a sapphyrin or a texaphyrin in a desired order in an automated or manual DNA synthesizer having a solid support to form a sapphyrin- or a texaphyrin-oligonucleotide conjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.