N.sup.6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5565566A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 26, 1995 |
| Grant date | Oct 15, 1996 |
| Priority date | — |
| Expiry date | Jan 26, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds and a method of using them to antagonize adenosine receptors are provided wherein the compounds are selected from the group of racemic mixtures or optically active compounds represented by the general formula: ##STR1## wherein R.sub.2 is selected from the group consisting of cycloalkyl radicals having from 3 to 8, preferably 3 to 7, ring carbon atoms, alkyl radicals having from 1 to 10, carbon atoms, aralkyl radicals having from 7 to 14, preferably 7 to 10, carbon atoms, and heteroatom- and halogen-substituted derivatives thereof wherein said heteroatom may be selected from the group consisting of nitrogen, phosphorus, sulfur and oxygen; R.sub.1 may be hydrogen or R.sub.2, and R.sub.3 is selected from the group consisting of hydrogen, halogen, amine, carboxy, thio, sufonate, sulfonamide, sulfone, sulfoxamide, phenyl, alkyl-substituted amine, cycloalkyl-substituted amine, alkyl radicals having from 1 to 10 carbon atoms, and cycloalkyl radicals having from 3 to 8, preferably 5 to 6, ring carbon atoms. R.sub.4 is selected from the group consisting of benzyl, phenyl, and alkyl groups comprising from 1 to 4 carbon atoms, wherein said alkyl group can be substituted with o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.