HIV-3 retrovirus and its use
US5567603A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 15, 1994 |
| Grant date | Oct 22, 1996 |
| Priority date | — |
| Expiry date | Apr 15, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/809
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described is a new retrovirus designated HIV-3, samples of which have been deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. The morphological and immunological properties exhibited by the HIV-3 retrovirus class include: PA1 a diameter of approximately 120 nm; a tropism for T4 lymphocytes; cultivation in T4 receptor-bearing immortalized cell lines; cytotoxicity for the lymphocytes that it infects; a magnesium dependent reverse transcriptase activity; PA1 the genomic RNA of HIV-3 hybridizes neither with the sequences of HIV-1 nor with the sequences of HIV-2 under stringent hybridization conditions; PA1 lysates of the virus contain a p25 protein which is immunologically distinct from the p19 protein of HTLV-I and the p24 proteins of HIV-1 and HIV-2 as determined by Western blot analysis, respectively; PA1 lysates of the virus contain a gp120 protein which is immunologically distinct from the gp110 protein of HTLV-I, the gp120 of HIV-1 and the gp120 of HIV-2 as determined by Western blot analysis; PA1 the lysate of the virus contains in addition a gp41 glycoprotein with a molecular weight of 40,000-45,000; and PA1 lysates of the virus contain a p12 …
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