Texaphyrins and uses thereof

US5567687A · kind A · utility

Assignees

• THE UNIVERSITY OF TEXAS · US
• Pharmacyclics LLC · US

Inventors

• Darren Magda · Cupertino, US
• Jonathan L. Sessler · Austin, US
• Brent L. Iverson · Austin, US
• Petra L. Jansen · Austin, US
• Meredith Wright · San Jose, US
• Tarak D. Mody · Sunnyvale, US
• Gregory W. Hemmi · Austin, US

Key dates

• Filing date: Sep 21, 1994
• Grant date: Oct 22, 1996
• Expiry date: Sep 21, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3511
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A texaphyrin having substituents containing ethoxy groups, methods for using texaphyrins in photodynamic therapy, and cleavage of a polymer of deoxyribonucleic acid are disclosed. The in vivo treatment of tumors and atheroma is demonstrated using Lu(III)texaphyrin complexes. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.