Nuclease resistant compounds
US5567810A · kind A · utility
210Cited by
1References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 31, 1995 |
| Grant date | Oct 22, 1996 |
| Priority date | — |
| Expiry date | May 31, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.