Palladium catalyzed ring closure of triazolyltryptamine
US5567824A · kind A · utility
6Cited by
1References
21Claims
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Key dates
| Filing date | May 24, 1994 |
| Grant date | Oct 22, 1996 |
| Priority date | — |
| Expiry date | May 24, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new process is described for the synthesis of the triazolyl tryptamine: ##STR1## and related compounds. The process involves a palladium-catalyzed ring closure between a substituted ortho-iodoaniline and a protected 1-alkynol. The process is carded out at high temperature, e.g. 100.degree. C., in a dry inert solvent, e.g., DMF and in the presence of a proton acceptor, e.g., Na.sub.2 CO.sub.3 or a trialkylamine. The triazolyl tryptamine, as well as acid addition salts thereof, is a 5 HT.sub.1 D receptor agonist having anti-migraine properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.