Process for the preparation of microballs and microballs thus obtained
US5569467A · kind A · utility
16Cited by
8References
43Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 16, 1994 |
| Grant date | Oct 29, 1996 |
| Priority date | — |
| Expiry date | May 16, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1694
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of making microballs is disclosed. An active ingredient, a biocompatible polymer and a supporting phase, such as silicone oil, are stirred at a temperature above the Tg of the polymer and below the temperature at which any of the ingredients vaporizes or degrades. Stirring is continued until microballs of the desired diameter are formed, whereafter the mixture is cooled and the microballs are separated from the supporting phase. The microballs are substantially spherical, substantially smooth on their external surface and have substantially no active ingredient on their external surface.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.