RNA import elements for transport into mitochondria
US5569754A · kind A · utility
15Cited by
0References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 11, 1993 |
| Grant date | Oct 29, 1996 |
| Priority date | — |
| Expiry date | Jun 11, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/22
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to small RNAs encoded within the nucleus of mammalian cells that specifically import to the mitochondria. The RNAs bind to several nucleolar peptides and thus provide potential carriers for import of biological molecules, including metabolites and proteins, into the mitochondrial compartment. Mitochondrial dysfunction in several maternally inherited human diseases may be correctable employing linkage of mitochondrial import signal to mitochondrial tRNA sequences expressed from nuclear trans-genes without requirement for direct genetic transformation of mitochondria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.