Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds
US5569762A · kind A · utility
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2Claims
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Key dates
| Filing date | Mar 22, 1995 |
| Grant date | Oct 29, 1996 |
| Priority date | — |
| Expiry date | Mar 22, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R.sub.1, R.sub.50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.