Fully integrated miniaturized planar liquid sample handling and analysis device

US5571410A · kind A · utility

Assignee

• Hewlett-Packard Company, L.P. · US

Inventors

• Sally A. Swedberg · Santa Cruz, US
• Patrick Kaltenbach · Bischweier, DE
• Klaus Witt · Keltern, DE
• Fritz Bek · Remchingen, DE
• Laurie S. Mittelstadt · Belmont, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Nov 5, 1996
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/303
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A miniaturized total analysis system (".mu.-TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The .mu.-TAS comprises microstructures fabricated by laser ablation in a variety of novel support substrates. The .mu.-TAS includes associated laser-ablated features required for integrated sample analysis, such as analyte detection means and fluid communication means. .mu.-TAS constructed according to the invention is useful in any analysis system for detecting and analyzing small and/or macromolecular solutes in the liquid phase and may employ chromatographic separation means, electrophoretic separation means, electrochromatographic separation means, or combinations thereof.