Recombinant antibodies specific for a growth factor receptor

US5571894A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Winfried Wels · Emmendingen, DE
• Nancy Hynes · Basel, CH
• Ina-Maria Harweth · Weil am Rhein, DE
• Bernd Groner · Basel, CH
• Norman Hardman · Riehen, CH
• Markus Zwickl · Mittelbiberach, DE

Key dates

• Filing date: Apr 29, 1994
• Grant date: Nov 5, 1996
• Expiry date: Apr 29, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies directed to c-erbB-2 themselves, a method of manufacturing those recombinant and monoclonal antibodies, hybridoma cells secreting those monoclonal antibodies, a method of manufacturing those hybridoma cells, DNAs encoding the heavy and light chain variable domains and the recombinant antibody, a method of manufacturing that DNA, hybrid vectors suitable for the expression of that DNA, host cells transformed with that DNA, and processes of using those recombinant and monoclonal antibodies in the diagnosis and treatment of tumors.