Patent · US Expired

Assay method based upon refractive index changes at a solid optical surface

US5573956A · kind A · utility

40Cited by
5References
14Claims
0Family size

Inventor

Key dates

Filing dateFeb 18, 1994
Grant dateNov 12, 1996
Priority date—
Expiry dateFeb 18, 2014

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10S436/805
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

A method of assaying for an analyte in a fluid sample comprises detecting the presence of the analyte by determining the resulting change in refractive index at a solid optical surface in contact with the sample, which change is caused by the analyte involving or influencing the binding or release of a refractive index-enhancing species to or from, respectively, the optical surface. Determination is performed with light having a wavelength at or near the maximum of the negative derivative of the absorptivity with respect to wavelength of the refractive index-enhancing species to obtain maximum sensitivity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.