Muscarine antagonists

US5574044A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Wayne Thompson · Lansdale, US
• Michael F. Sugrue · Blue Bell, US
• Richard W. Ransom · Doylestown, US
• Pierre Mallorga · Lansdale, US
• Ian M. Bell · Harleysville, US
• Anthony M. Smith · Green Lane, US

Key dates

• Filing date: Oct 27, 1994
• Grant date: Nov 12, 1996
• Expiry date: Oct 27, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds, 1,3-dihydro-1-{1-[piperidin-4-yl]piperidin-4-yl}-2H-benzimidazol-2-ones and 1,3-dihydro-1-{4-amino-1-cyclohexyl}-2H-benzimidazol-2-ones and derivatives thereof, their preparation, method of use and pharmaceutical compositions are described. These compounds are endowed with antimuscarinic activity and are useful in the treatment and/or prevention of myopia (commonly known as nearsightedness).