Pharmaceutical aqueous formulations containing a sparingly soluble pharmaceutical active compound with a solubilizing polymeric agent

US5576012A · kind A · utility

Inventors

• Kurt Bauer
• Markus Kiefer · Bad Krozingen, DE

Key dates

• Filing date: Aug 10, 1993
• Grant date: Nov 19, 1996
• Expiry date: Aug 10, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F20/58
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pharmaceutical formulations which comprise at least one pharmaceutical active compound in combination with a polymer of the general formula I or I', in particular for intravenous administration, ##STR1## in which R.sub.1, R.sub.2, R.sub.5 and R.sub.6 are identical or different and represent hydrogen and a methyl or ethyl group, PA1 Q represents a valency, oxygen or an ester or amide bridge and Q' denotes hydrogen if Q represents a valency or oxygen, and is a hydroxyl or amino group if Q represents an ester or amide bridge, PA1 x is an integer from 3 to 50, preferably 5 to 40, if Q is a valency or oxygen, and an integer from 3 to 1000, preferably 50 to 100, if Q is an ester or amide function, G.sub.1 and G.sub.2 are a valency, oxygen or an ester or amide group, it being possible for the two groups to be identical or different, n is an integer from 4 to 44, preferably 12 to 16, PA1 y is an integer from 2 to 50, preferably 10 to 40, and R.sub.3 is hydrogen or a lower alkyl having 1-6 C atoms.