Galanin antagonist

US5576296A · kind A · utility

Assignee

• ASTRA CO., LTD. · SE

Inventors

• Tamas Bartfai · Stockholm, SE
• Tomas H okfelt · Djursholm, SE
• Ulo Langel · Tartu, EE
• Bo Ahr en · Lund, SE
• Stefan Lindskog · Lund, SE
• Silvana Consolo · Milano, IT
• Tiit Land · Stockholm, SE
• Zsuzsanna Wiesenfeld-Hallin · Stockholm, SE

Key dates

• Filing date: Jun 6, 1995
• Grant date: Nov 19, 1996
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A galanin antagonist which is a galanin receptor ligand is described. New peptides, Galanin (1-12)-Pro-Substance P(5-11), Galanin (1-12)-Pro-Bradykinin(2-9), Galanin (1-12)-Pro-Pro-Pro- (Leu.sup.5 -Enkephalin (5-1), Galanin (1-12)-Pro-Lys(.epsilon.-NH-)Pro-(Leu5-Enkephalin (5-1) and functional analogues and functional derivatives thereof are disclosed. The peptides are used in pharmaceutical preparations to treat a disorder in a mammal which depends on the physiological function of galanin at the galanin receptor.