11-benzaldoxime-17.beta.-methoxy-17.alpha.-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds

US5576310A · kind A · utility

Assignee

• Jenapharm GmbH · DE

Inventors

• Gerd Schubert · Jena, DE
• G unther Kaufmann · Jena, DE
• Lothar Sobeck · Jena, DE
• Michael Oettel · Jena, DE
• Walter Elger · Berlin, DE
• Anatoli Kurischko · Jena, DE

Key dates

• Filing date: Sep 20, 1994
• Grant date: Nov 19, 1996
• Expiry date: Sep 20, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J41/0083
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to new 11-benzaldoxime-estra-diene derivatives of the general formula I ##STR1## wherein Z is --CO--CH.sub.3, --CO--O--C.sub.2 H.sub.5, --CO--NH-phenyl, --CO--NH--C.sub.2 H.sub.5, --CO--C.sub.2 H.sub.5, --CH.sub.3, or --CO-phenyl and their pharmaceutically acceptable salts, a method for their production, and pharmaceuticals containing such compounds. The compounds of the general formula I are produced by esterifying or etherizing a compound of the general formula II ##STR2## The compounds described show strong antigestagenic effects combined with reduced glucocorticoid activity.