MCC protein and antibody

US5576422A · kind A · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• University of Utah · US
• The Cancer Institute · JP

Inventors

• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Raymond L. White · Salt Lake City, US
• Yusuke Nakamura · Bunkyo, JP

Key dates

• Filing date: May 19, 1995
• Grant date: Nov 19, 1996
• Expiry date: May 19, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/118
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A new human gene termed MCC is disclosed. Methods and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results suggest that MCC is a tumor suppressor. A MCC protein and antibody are disclosed.