5-substituted pyrimidine nucleosides and nucleotides

US5576429A · kind A · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Karl N. G. Johansson · Fagersta, SE
• Hans C. G. Malmberg · Hagfors, SE
• Rolf Noreen · Huddinge, SE
• S. Christer Sahlberg · Norsjö, SE
• Daniel Sohn · Gately Drive, SE
• Sal o Gronowitz · Lund, SE

Key dates

• Filing date: Feb 28, 1995
• Grant date: Nov 19, 1996
• Expiry date: Feb 28, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to compounds of formula (I), ##STR1## wherein R.sup.1 is OH, NH.sub.2 ; R.sup.2 is a heteroaromatic or aromatic substituent; R.sup.3 is H, OH, F, OCH.sub.3 ; R.sup.4 is H, F, OH or an ether or ester residue thereof, OCH.sub.3, CN, C.dbd.CH, N.sub.3 ; R.sup.5 is OH or an ether or ester residue thereof including mono, di- and triphosphate esters (.alpha.), wherein n is 0 or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic treatment of virus infections.