Thromboresistant surface treatment for biomaterials
US5578073A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Sep 16, 1994 |
| Grant date | Nov 26, 1996 |
| Priority date | — |
| Expiry date | Sep 16, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L33/062
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A biomaterial with a thromboresistant surface and a method for forming same are provided. The thromboresistant surface is comprised of a distinct coating layer of a chitosan-based membrane and a biologically active material. The biologically active material is capable of converting the chitosan membrane coating from a highly thrombogenic to an essentially non-thrombogenic one. The biologically active material can be a polymeric substance, such as polyvinyl alcohol, forming a polymeric blend with the chitosan, or, can be a biological substance, such as serum albumin, embedded in or attached to the chitosan membrane which has been activated with a treatment of glutardialdehyde. The thromboresistant biomaterial is suitable for use in vascular grafts having an inside diameter of less than 6 millimeters.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.