Partially modified and retro-inverted tetrapeptides analogues of C-reactive protein fragments
US5578575A · kind A · utility
1Cited by
2References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 28, 1996 |
| Grant date | Nov 26, 1996 |
| Priority date | — |
| Expiry date | Feb 28, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for treating septic shock by administering a retroinverted tetrapeptides of formula I ##STR1## wherein R is a hydrogen atom or the side-chain of threonine; R.sub.1 is the side-chain of arginine, leucine or glutamine; and R.sub.2 is a hydrogen atom or a metabolically perishable acyl group; with the proviso that when R.sub.1 is the side-chain of arginine, R cannot be the side-chain of threonine; diastereo-isomeric forms and pharmacologically acceptable salts, esters and amides thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.