Heterocyclic compounds which inhibit aromatase
US5578630A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 25, 1994 |
| Grant date | Nov 26, 1996 |
| Priority date | — |
| Expiry date | Nov 25, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/56
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to heterocyclic compounds which are inhibitors of the enzyme aromatase, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine. Particular compounds of the invention are compounds of formula (I) ##STR1## wherein R.sup.1 represents a cyano or nitro group; R.sup.2 represents hydrogen or one or more halogen atoms; PA1 R.sup.3 represents a C.sub.1-6 alkyl group and R.sup.4 represents hydrogen or a PA1 C.sub.1-6 alkyl group or R.sup.3 and R.sup.4 together represent a C.sub.3-6 cycloalkyl group; and PA1 R.sup.5 represents hydrogen or one or more halogen atoms or C.sub.1-6 alkoxy groups and pharmaceutically acceptable salts and solvates thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.