Styrene-isoprene-styrene copolymer-based transdermal matrix system for the administration of an oestrogen and/or a progestogen
US5580572A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 28, 1995 |
| Grant date | Dec 3, 1996 |
| Priority date | — |
| Expiry date | Mar 28, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P5/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is concerned with a new transdermal matrix system for the percutaneous administration of a hormone, said matrix system, which has a support and a self-adhesive matrix, comprising a matrix containing: PA0 (a) 20 to 42 parts by weight of a poly(styrene-isoprene-styrene) triblock copolymer, PA0 (b) 35 to 55 parts by weight of a tackifying resin. PA0 (c) 5 to 25 parts by weight of a plasticizing agent selected from the group consisting of oleic alcohol, peglicol 5-oleate, propyleneglycol laurate or a polypropoxyl ether of cetyl alcohol, PA0 (d) 5 to 15 parts by weight of at least one compound selected from the group consisting of: PA1 crotamiton, and PA1 N-substituted 2-pyrrolidones of formula I, ##STR1## wherein R represents a (C.sub.1 -C.sub.15)-alkyl, cyclohexyl or 2-hydroxyethyl group, PA0 (e) 0,01 to 1 part by weight of a stabilizing agent and, PA0 (f) 0,1 to 5 parts by weight of a hormone selected from the group consisting of oestrogen components, progestogen components and mixtures thereof. It also relates to a method for prepararing said system. No figure.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.