Therapeutic 1,4-thiazepines

US5580866A · kind A · utility

Assignee

• THE BOOTS COMPANY PLC · GB

Inventors

• John R. Housley · Matlock, GB
• James E. Jeffery · Nottingham, GB
• Kenneth J. Nichol · West Bridgford, GB
• Bruce Sargent · Nottingham, GB

Key dates

• Filing date: May 3, 1995
• Grant date: Dec 3, 1996
• Expiry date: May 3, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## in which n=0, 1 or 2; PA1 R.sub.1, R.sub.2, R.sub.6 and R.sub.7 independently represent H or alkyl (optionally substituted by one or more halo); PA1 R.sub.3 and R.sub.4 independently represent H or alkyl or together represent a group of formula .dbd.NR.sub.12 where R.sub.12 represents H, hydroxy, alkyl, phenyl or alkoxy; each alkyl, phenyl and alkoxy being optionally substituted with one or more halo; PA1 R.sub.5 represents: (a) H, (b) alkyl, (c) a group of formula --COR.sub.13 in which R.sub.13 is H, alkyl or phenyl, when R.sub.3 and R.sub.4 represent H or alkyl (optionally substituted with one or more halo), or (d) a group of formula --S(O).sub.p R.sub.14 in which p=1 or 2 and R.sub.14 is alkyl or phenyl, when R.sub.3 and R.sub.4 represent H or alkyl (optionally substituted with one or more halo); each alkyl and phenyl optionally substituted with one or more halo; PA1 and R.sub.8 to R.sub.11 independently represent H, halo, cyano, nitro, alkyl alkoxy, alkanoyl, carboxy, alkanoyloxy, carbamoyl (optionally substituted with alkyl or sulphamoyl (optionally substituted with alkyl of 1 to 4 carbon atoms); each alkyl, alkoxy, alkanoyl or alkanoyloxy optio…