Myocardial protection during ischemia and reperfusion
US5580867A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 9, 1994 |
| Grant date | Dec 3, 1996 |
| Priority date | — |
| Expiry date | Sep 9, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D281/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Myocardial protection is achieved by administering to a patient an effective amount of a benzothiazepine derivative. The benzothiazepine derivatives have the following general chemical formula: ##STR1## wherein R.sub.1 represents hydrogen or methyl, PA1 R.sub.2 represents hydrogen or acetyl, PA1 R.sub.3 represents hydrogen or methyl, and PA1 R.sub.4 represents hydrogen or a halogen, PA1 with the proviso that R.sub.1 cannot be methyl when R.sub.2 =acetyl, R.sub.3 =methyl and R.sub.4 =hydrogen. The above compounds may also be used in other clinical conditions such as treatment of stable and unstable angina, non-Q-wave myocardial infarction, cerebral trauma ischemia and reperfusion, organ graft preservation, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.