1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl- (8a.beta.)-6-isoquinolineamine derivatives, preparation method therefor and therapeutical use thereof
US5580881A · kind A · utility
10Cited by
2References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 27, 1995 |
| Grant date | Dec 3, 1996 |
| Priority date | — |
| Expiry date | Apr 27, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8a.beta.)-isoquinolineamines of formula (I), wherein groups R.sup.1 -R.sup.3 are as defined in the description, a method for preparing same, and therapeutical uses thereof as agents for inhibiting the biosynthesis of cholesterol, particularly epoxysqualene cyclase, which are useful as cholesterol and lipid lowering drugs, antiatheromatic and antifungal agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.