Process for the production of 1-.alpha.-(carboxyalkyl)-testosterone
US5581002A · kind A · utility
0Cited by
14References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 28, 1995 |
| Grant date | Dec 3, 1996 |
| Priority date | — |
| Expiry date | Apr 28, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/812
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention discloses a process for making 1-.alpha.-(carboxyalkyl)testosterone having the following formula: ##STR1## The process involves protecting the 17 position of 1,4-androstadien-17 .beta.-ol-3-one with TBDMS, alkylating with an alkenylmagnesium bromide and ozonolyzing the resulting ether. The resulting product is oxidized with sodium hypochloride followed by removal of the TBDMS protecting group with aqueous hydrofluoric acid in acetonitrile to produce the 1-.alpha.-(carboxyalkyl)-testosterone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.