Rapid diagnostic procedure for ivermectin resistance
US5583008A · kind A · utility
7Cited by
4References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 19, 1993 |
| Grant date | Dec 10, 1996 |
| Priority date | — |
| Expiry date | May 19, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/43534
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention is directed to a rapid, efficient, inexpensive screening and diagnostic procedure for detecting avermectin/milbemycin resistance in parasitic nematodes. The procedure is designed for field use. The method entails the incubation of nematode sensillum with specific visible or fluorescent dyes that intercalate and diffuse in membranes of sensory neurons on the outer surface of wild-type nematodes but which do not bind or have reduced binding in resistant nematodes. The method is particularly directed to ivermectin resistant parasitic nematodes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.