Method of cleaving specific strands of RNA

US5583032A · kind A · utility

Assignee

• The Cleveland Clinic Foundation and National Institutes of Health · US

Inventors

• Paul F. Torrence · Gaithersburg, US
• Robert H. Silverman · Shaker Heights, US
• Ratan Maitra · Euclid, US
• Krystyna Lesiak · Gaithersburg, US

Key dates

• Filing date: Sep 17, 1993
• Grant date: Dec 10, 1996
• Expiry date: Sep 17, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/143333
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.